Biocomputing Model Using Tripartite Synapses Provides Reliable Neuronal Logic Gating with Spike Pattern Diversity

Biocomputing technologies exploit biological communication mechanisms involving cell-cell signal propagation to perform computations. Researchers recently worked toward realising logic gates made by neurons to develop novel devices such as organic neuroprostheses or brain implants made by cells, herein termed living implants. Several challenges arise from this approach, mainly associated with the stochastic nature and noise of neuronal communication. Since astrocytes play a crucial role in the regulation of neurons activity, there is a possibility whereby astrocytes can be engineered to control synapses favouring reliable biocomputing. This work proposes a mathematical model of neuronal logic gates involving neurons and astrocytes, realising OR and AND gating. We use a shallow coupling of both the Izhikevich and Postnov models to characterise gating responses with spike pattern variability and astrocyte synaptic regulation. Logic operation error ratio and accuracy assess the AND and OR gates' performances at different synaptic Gaussian noise levels. Our results demonstrate that the astrocyte regulating activity can effectively be used as a denoising mechanism, paving the way for highly reliable biocomputing implementations.Comment: Submitted for journal publication 202

Feed-forward and Feedback Control in Astrocytes for Ca2+-based Molecular Communications Nanonetworks

Synaptic plasticity depends on the gliotransmitters’ concentration in the synaptic channel. And, an abnormal concentration of gliotransmitters is linked to neurodegenerative diseases, including Alzheimer’s, Parkinson’s, and epilepsy. In this paper, a theoretical investigation of the cause of the abnormal concentration of gliotransmitters and how to achieve its control is presented through a Ca2+-signalling-based molecular communications framework. A feed-forward and feedback control technique is used to manipulate IP3 values to stabilise the concentration of Ca2+ inside the astrocytes. The theoretical analysis of the given model aims i) to stabilize the Ca2+ concentration around a particular desired level in order to prevent abnormal gliotransmitters’ concentration (extremely high or low concentration can result in neurodegeneration), ii) to improve the molecular communication performance that utilises Ca2+ signalling, and maintain gliotransmitters’ regulation remotely. It shows that the refractory periods from Ca2+ can be maintained to lower the noise propagation resulting in smaller time-slots for bit transmission, which can also improve the delay and gain performances. The proposed approach can potentially lead to novel nanomedicine solutions for the treatment of neurodegenerative diseases, where a combination of nanotechnology and gene therapy approaches can be used to elicit the regulated Ca2+ signalling in astrocytes, ultimately improving neuronal activity

Biocomputing Model Using Tripartite Synapses Provides Reliable Neuronal Logic Gating with Spike Pattern Diversity.

Biocomputing technologies exploit biological communication mechanisms involving cell-cell signal propagation to perform computations. Researchers recently worked toward realising logic gates made by neurons to develop novel devices such as organic neuroprostheses or brain implants made by cells, herein termed living implants. Several challenges arise from this approach, mainly associated with the stochastic nature and noise of neuronal communication. Since astrocytes play a crucial role in the regulation of neurons activity, there is a possibility whereby astrocytes can be engineered to control synapses favouring reliable biocomputing. This work proposes a mathematical model of neuronal logic gates involving neurons and astrocytes, realising OR and AND gating. We use a shallow coupling of both the Izhikevich and Postnov models to characterise gating responses with spike pattern variability and astrocyte synaptic regulation. Logic operation error ratio and accuracy assess the AND and OR gates' performances at different synaptic Gaussian noise levels. Our results demonstrate that the astrocyte regulating activity can effectively be used as a denoising mechanism, paving the way for highly reliable biocomputing implementations

Explorando o Potencial da Molécula IP3 para a Comunicação em Nanorredes

Advances in bioengineering and nanotechnology have allowed the emergence of nanometer-sized devices, e.g., synthetic nanomachines, nanoantennas and nanoinjectors, able of detecting and actuating their environment. However, despite necessary, it is a big challenge to master the communication among them. The conventional electromagnetic communication is not a direct choice for nanonetworks in some specific medium and due to their scale. Hence, researchers have explored molecular communication. Particularly, this paper investigates the potential of the Inositol Triphosphate (IP3) molecule for data communication between nanodevices. We evaluate the space-time concentration of the IP3 molecule and how intracellular signaling inflluences over it in neuron cells (astrocytes). Compared to the calcium molecule performance, results from gain and channel communication are promising and assist in a further understanding of how to manage extracellular data transmission

Quality and Capacity Analysis of Molecular Communications in Bacterial Synthetic Logic Circuits

Synthetic logic circuits have been proposed as potential solutions for theranostics of biotechnological problems. One proposed model is the engineering of bacteria cells to create logic gates, and the communication between the bacteria populations will enable the circuit operation. In this paper, we analyse the quality of bacteria-based synthetic logic circuit through molecular communications that represent communication along a bus between three gates. In the bacteria-based synthetic logic circuit, the system receives environmental signals as molecular inputs and will process this information through a cascade of synthetic logic gates and free diffusion channels. We analyse the performance of this circuit by evaluating its quality and its relationship to the channel capacity of the molecular communications links that interconnect the bacteria populations. Our results show the effect of the molecular environmental delay and molecular amplitude differences over both the channel capacity and circuit quality. Furthermore, based on these metrics we also obtain an optimum region for the circuit operation resulting in an accuracy of 80% for specific conditions. These results show that the performance of synthetic biology circuits can be evaluated through molecular communications, and lays the groundwork for combined systems that can contribute to future biomedical and biotechnology applications

Digital Twin for Metasurface Reflector Management in 6G Terahertz Communications

The performance demands from data-intensive applications, such as multimedia streaming, as well as the growing number of devices connecting to the Internet, will increase the need for higher capacity wireless communication links. The research community has recently explored regions of the spectrum, including the Terahertz band (0.1 THz to 10 THz), that are underutilised for communications. THz frequencies come with a plethora of special challenges, one of which is the very narrow effective beam, thereby requiring a Line of Sight (LoS) between sender and receiver. Researchers have explored the use of reflectors that can redirect beams around blockages. In this paper, we propose a THz signal guidance system where a Digital Twin is used to model, predict and control the signal propagation characteristics of an indoor space. Our approach finds the best THz signal path from the base station to the mobile target via the tunable metamaterial walls, avoiding obstacles as needed, using geometric (ray tracing), path loss and Terahertz Potential Field (THzPF) models. With this knowledge, the digital twin guides the selection of antenna strips at a base station and the reflectors along the signal path. A top-view camera, with advanced image processing, provides context updates (obstacle and mobile target locations) to the digital twin. The image processing system also senses factors like water vapour concentration, and the material composition and surface roughness of obstacles. Such factors affect propagation strength, and the digital twin modifies the beam paths to adapt. Simulation results have shown the efficiency of our control system to maintain a reliable signal connection while minimising the use of antenna and reflector strips. Our system is the first proposal that maximises THz signal-to-noise ratio (SNR) through such a dynamic and robust control system, which integrates image processing of a room with base station configuration